Cachexia is a multifactorial wasting syndrome associated with high morbidity and mortality\nin patients with cancer. Diagnosis can be difficult and, in the clinical situation, usually relies upon\nreported weight loss. The â??omicsâ?? technologies allow us the opportunity to study the end points\nof many biological processes. Among these, blood-based metabolomics is a promising method to\ninvestigate the pathophysiology of human cancer cachexia and identify candidate biomarkers. In this\nstudy, we performed liquid chromatography mass spectrometry (LC/MS)-based metabolomics to\ninvestigate the metabolic profile of cancer-associated weight loss. Non-selected patients undergoing\nsurgery with curative intent for upper gastrointestinal cancer were recruited. Fasting plasma\nsamples were taken at induction of anaesthesia. LC/MS analysis showed that 6 metabolites were\nhighly discriminative of weight loss. Specifically, a combination profile of LysoPC 18.2, L-Proline,\nHexadecanoic acid, Octadecanoic acid, Phenylalanine and LysoPC 16:1 showed close correlation for\neight weight-losing samples .........................
Loading....